Target General Information
Target ID T95678
Target Name Influenza Proton channel protein (M2)
Gene Name M2
Species Influenza A viruses H1N1
UniProt ID M2_I35A3
Sequence MSLLTEVETPIRNEWGCRCNGSSDPLVIAASIIGILHLILWILDRLLFKCIYRRFKYGLK
RGPSTEGVPESMREEYRKEQQSAVDADDGHFVNIEPE [Influenza A viruses H
1N1]
Drug and Corresponding Resistance Mutations
Mutation Info Missense: S31N
Drugs
Drug Name Amantadine Drug Info [1], [2]
Targeted Disease Influenza virus infection
Drug Name Memantine Drug Info [3]
Targeted Disease Influenza virus infection
Drug Name Oseltamivir Drug Info [1]
References
REF 1 Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses. Eur J Med Chem. 2017 Jul 28;135:70-76.
REF 2 Investigation of a recent rise of dual amantadine-resistance mutations in the influenza A M2 sequence.BMC Genet.2015;16 Suppl 2:S3.
REF 3 Discovery of Potential, Non-Toxic Influenza Virus Inhibitor by Computational Techniques. Mol Inform. 2014 Aug;33(8):559-65.

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