Resistance mutation info of target
Target General Information | ||||||||||||||||||
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Target ID | T96760 | |||||||||||||||||
Target Name | Growth differentiation factor-5 (GDF5) | |||||||||||||||||
Gene Name | GDF5 | |||||||||||||||||
Species | Homo sapiens | |||||||||||||||||
UniProt ID | GDF5_HUMAN | |||||||||||||||||
Sequence |
MRLPKLLTFLLWYLAWLDLEFICTVLGAPDLGQRPQGTRPGLAKAEAKERPPLARNVFRP GGHSYGGGATNANARAKGGTGQTGGLTQPKKDEPKKLPPRPGGPEPKPGHPPQTRQATAR TVTPKGQLPGGKAPPKAGSVPSSFLLKKAREPGPPREPKEPFRPPPITPHEYMLSLYRTL SDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPVVRKQRYVFDISALEKDGLLGAELR ILRKKPSDTAKPAAPGGGRAAQLKLSSCPSGRQPASLLDVRSVPGLDGSGWEVFDIWKLF RNFKNSAQLCLELEAWERGRAVDLRGLGFDRAARQVHEKALFLVFGRTKKRDLFFNEIKA RSGQDDKTVYEYLFSQRRKRRAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIA PLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFID SANNVVYKQYEDMVVESCGCR [Homo sapiens] |
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Drug and Corresponding Resistance Mutations | ||||||||||||||||||
Mutation Info | Missense: N445K | |||||||||||||||||
Drugs |
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Mutation Info | Missense: N445T | |||||||||||||||||
Drugs |
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References | ||||||||||||||||||
REF 1 | Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.PLoS Genet.2009 Nov;5(11):e1000747. |
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