Resistance mutation info of target
| Target General Information | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Target ID | T98089 | ||||||||||||
| Target Name | Deoxycytidine kinase (DCK) | ||||||||||||
| Gene Name | DCK | ||||||||||||
| Species | Homo sapiens | ||||||||||||
| UniProt ID | DCK_HUMAN | ||||||||||||
| Sequence |
MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKSTFVNILKQLCEDWEVVPEPVARWCN VQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFTFQTYACLSRIRAQLASLNGKLKDAE KPVLFFERSVYSDRYIFASNLYESECMNETEWTIYQDWHDWMNNQFGQSLELDGIIYLQA TPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESWLLHRTLKTNFDYLQEVPILTLDVNE DFKDKYESLVEKVKEFLSTL [Homo sapiens] |
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| Drug and Corresponding Resistance Mutations | |||||||||||||
| Mutation Info | Missense: E197K | ||||||||||||
| Drugs |
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| References | |||||||||||||
| REF 1 | Acquisition of chemoresistance to gemcitabine is induced by a loss-of-function missense mutation of DCK.Biochem Biophys Res Commun.2015 Sep 4;464(4):1084-9. | ||||||||||||
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