Drug Information

Drug General Information
Drug ID
DX0YLK
Drug Name
(R)-2-(4-Morpholin-4-yl-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid hydroxyamide
Synonyms
CHEMBL294680
Indication Discovery agent Investigative [1587926]
Formula
C22H24N4O5S
Canonical SMILES
ONC(=O)[C@H]1Cc2c(CN1S(=O)(=O)c3ccc(cc3)N4CCOCC4)[nH]c5ccccc25
InChI
InChI=1S/C22H24N4O5S/c27-22(24-28)21-13-18-17-3-1-2-4-19(17)23-20(18)14-26(21)32(29,30)16-7-5-15(6-8-16)25-9-11-31-12-10-25/h1-8,21,23,28H,9-14H2,(H,24,27)/t21-/m1/s1
InChIKey
PSFVLJSHQMPQKQ-OAQYLSRUSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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