Drug Information

Drug General Information
Drug ID
DX1SCI
Drug Name
(R)-2-(4-Phenoxy-benzenesulfonyl)-2,3,4,9-tetrahydro-1H-beta-carboline-3-carboxylic acid
Synonyms
CHEMBL443478
Indication Discovery agent Investigative [1587926]
Formula
C24H20N2O5S
Canonical SMILES
OC(=O)[C@H]1Cc2c(CN1S(=O)(=O)c3ccc(Oc4ccccc4)cc3)[nH]c5ccccc25
InChI
InChI=1S/C24H20N2O5S/c27-24(28)23-14-20-19-8-4-5-9-21(19)25-22(20)15-26(23)32(29,30)18-12-10-17(11-13-18)31-16-6-2-1-3-7-16/h1-13,23,25H,14-15H2,(H,27,28)/t23-/m1/s1
InChIKey
YDDLGJKZEJWWDF-HSZRJFAPSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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