Drug Information

Drug General Information
Drug ID
DX3MYI
Drug Name
Deuterated 6-Methyl-3-(1H-pyrazol-4-tl)-N-[3-[[(3,3,3-trifluoropropyl)amino]methyl-(d2)]-5-isothiazolyl]imidazo[1,2-a]pyrazin-8-amine Hydrochloride
Synonyms
CHEMBL1650553
Indication Discovery agent Investigative [1587926]
Formula
C17H16ClD2F3N8S
Canonical SMILES
Cl.[2H]C([2H])(NCCC(F)(F)F)c1cc(Nc2nc(C)cn3c(cnc23)c4cn[nH]c4)sn1
InChI
InChI=1S/C17H17F3N8S.ClH/c1-10-9-28-13(11-5-23-24-6-11)8-22-16(28)15(25-10)26-14-4-12(27-29-14)7-21-3-2-17(18,19)20;/h4-6,8-9,21H,2-3,7H2,1H3,(H,23,24)(H,25,26);1H/i7D2;
InChIKey
IZQBDZNNSDJCSW-YNWPSCTISA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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