Drug Information
| Drug General Information | |||||
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| Drug ID |
DX4BW8
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| Drug Name |
(3R,5S)-5-((4-(1-benzyl-3-fluoro-1H-indol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL452980
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C32H29FN6O3S
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| Canonical SMILES |
Fc1cn(Cc2ccccc2)c3ccc(Nc4ncnc5cc(C#C[C@@H]6C[C@H](CN6)OC(=O)N7CCOCC7)sc45)cc13
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| InChI |
InChI=1S/C32H29FN6O3S/c33-27-19-39(18-21-4-2-1-3-5-21)29-9-7-23(15-26(27)29)37-31-30-28(35-20-36-31)16-25(43-30)8-6-22-14-24(17-34-22)42-32(40)38-10-12-41-13-11-38/h1-5,7,9,15-16,19-20,22,24,34H,10-14,17-18H2,(H,35,36,37)/t22-,24-/m1/s1
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| InChIKey |
VURXMUNOWCBINZ-ISKFKSNPSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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