Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX4POI
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| Drug Name |
(2E)-N-(4-{[4-(benzyloxy)-3,6-dioxocyclohexa-1,4-dien-1-yl]amino}-7-ethoxyquinazolin-6-yl)-4-(dimethylamino)but-2-enamide
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| Synonyms |
CHEMBL243629
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C29H29N5O5
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| Canonical SMILES |
CCOc1cc2ncnc(NC3=CC(=O)C(=CC3=O)OCc4ccccc4)c2cc1NC(=O)\\C=C\\CN(C)C
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| InChI |
InChI=1S/C29H29N5O5/c1-4-38-26-15-21-20(13-23(26)32-28(37)11-8-12-34(2)3)29(31-18-30-21)33-22-14-25(36)27(16-24(22)35)39-17-19-9-6-5-7-10-19/h5-11,13-16,18H,4,12,17H2,1-3H3,(H,32,37)(H,30,31,33)/b11-8+
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| InChIKey |
OZJNFEMRGXMBKA-DHZHZOJOSA-N
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| Target and Pathway | |||||
| Target(s) | Vascular endothelial growth factor receptor 2 | Target Info | [1587926] | ||
| Epidermal growth factor receptor III | Target Info | [1587926] | |||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Angiogenesis | ||||
| VEGF signaling pathway | |||||
| Pathway Interaction Database | HIF-2-alpha transcription factor network | ||||
| Beta3 integrin cell surface interactions | |||||
| Signaling events mediated by TCPTP | |||||
| SHP2 signaling | |||||
| S1P1 pathway | |||||
| VEGF and VEGFR signaling network | |||||
| Integrins in angiogenesis | |||||
| Signaling events mediated by VEGFR1 and VEGFR2 | |||||
| Notch-mediated HES/HEY network | |||||
| References | |||||
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