Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX5OAX
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| Drug Name |
[3-Chloro-4-(3-fluoro-benzyloxy)-phenyl]-{6-[2-(2-methanesulfonyl-ethylamino)-thiazol-4-yl]-quinazolin-4-yl}-amine
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| Synonyms |
CHEMBL155761
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C27H23ClFN5O3S2
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| Canonical SMILES |
CS(=O)(=O)CCNc1nc(cs1)c2ccc3ncnc(Nc4ccc(OCc5cccc(F)c5)c(Cl)c4)c3c2
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| InChI |
InChI=1S/C27H23ClFN5O3S2/c1-39(35,36)10-9-30-27-34-24(15-38-27)18-5-7-23-21(12-18)26(32-16-31-23)33-20-6-8-25(22(28)13-20)37-14-17-3-2-4-19(29)11-17/h2-8,11-13,15-16H,9-10,14H2,1H3,(H,30,34)(H,31,32,33)
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| InChIKey |
LJOCIHRQARKISZ-UHFFFAOYSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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