Drug Information

Drug General Information
Drug ID
DX6ZDK
Drug Name
4-(5-Methyl-1H-pyrazol-3-ylamino)-2-(4-nitrobenzyl)-2Hphthalazin-1-one
Synonyms
CHEMBL1651483
Indication Discovery agent Investigative [1587926]
Formula
C19H16N6O3
Canonical SMILES
Cc1cc(NC2=NN(Cc3ccc(cc3)[N+](=O)[O-])C(=O)c4ccccc24)n[nH]1
InChI
InChI=1S/C19H16N6O3/c1-12-10-17(22-21-12)20-18-15-4-2-3-5-16(15)19(26)24(23-18)11-13-6-8-14(9-7-13)25(27)28/h2-10H,11H2,1H3,(H2,20,21,22,23)
InChIKey
HIQIMBYLAJXNOK-UHFFFAOYSA-N
Target and Pathway
Target(s) Aurora kinase A Target Info [1587926]
Aurora kinase B Target Info [1587926]
KEGG Pathway Oocyte meiosis
Pathway Interaction Database Aurora B signaling
Signaling by Aurora kinases
Integrin-linked kinase signaling
PLK1 signaling events
Aurora A signalingaurora_b_pathway:Aurora B signaling
Aurora C signaling
FOXM1 transcription factor network
Aurora A signaling
Reactome APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Regulation of PLK1 Activity at G2/M TransitionR-HSA-174178:APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways EGF/EGFR Signaling Pathway
JAK/STAT
Gastric Cancer Network 1
Integrated Breast Cancer Pathway
APC/C-mediated degradation of cell cycle proteinsWP2757:Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Regulation of Microtubule Cytoskeleton
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
APC/C-mediated degradation of cell cycle proteins
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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