Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX7GII
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| Drug Name |
(1S,2R,3R)-1-{(R)-4-[5-(1,1-Difluoroethyl)isoxazol-3-yl]-3-methylpiperazine-1-sulfonylamino}-2-methyl-3-phenylcyclopropanecarboxylic Acid
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| Synonyms |
CHEMBL1766917
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C21H26F2N4O5S
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| Canonical SMILES |
C[C@@H]1CN(CCN1c2cc(on2)C(C)(F)F)S(=O)(=O)N[C@]3([C@H](C)[C@@H]3c4ccccc4)C(=O)O
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| InChI |
InChI=1S/C21H26F2N4O5S/c1-13-12-26(9-10-27(13)17-11-16(32-24-17)20(3,22)23)33(30,31)25-21(19(28)29)14(2)18(21)15-7-5-4-6-8-15/h4-8,11,13-14,18,25H,9-10,12H2,1-3H3,(H,28,29)/t13-,14-,18-,21+/m1/s1
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| InChIKey |
WQDCDSSZTJOWCF-PHAJSTNCSA-N
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| Target and Pathway | |||||
| Target(s) | Interstitial collagenase | Target Info | [1587926] | ||
| Matrix metalloproteinase-14 | Target Info | [1587926] | |||
| Pathway Interaction Database | Endothelins | ||||
| Validated transcriptional targets of AP1 family members Fra1 and Fra2 | |||||
| Glucocorticoid receptor regulatory network | |||||
| AP-1 transcription factor network | |||||
| Syndecan-1-mediated signaling eventshif2pathway:HIF-2-alpha transcription factor network | |||||
| Signaling events mediated by focal adhesion kinase | |||||
| WikiPathways | TGF beta Signaling Pathway | ||||
| Bladder Cancer | |||||
| Activation of Matrix Metalloproteinases | |||||
| Degradation of collagen | |||||
| Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis | |||||
| Oncostatin M Signaling Pathway | |||||
| Prostate Cancer | |||||
| Integrated Breast Cancer Pathway | |||||
| Integrated Cancer pathway | |||||
| Cell surface interactions at the vascular wall | |||||
| Matrix MetalloproteinasesWP615:Senescence and Autophagy in Cancer | |||||
| AGE/RAGE pathway | |||||
| Matrix Metalloproteinases | |||||
| References | |||||
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