Drug Information

Drug General Information
Drug ID
DX8L7E
Drug Name
3-benzyl-7-hydroxy-4-(trifluoromethyl)-2H-chromen-2-one
Synonyms
CHEMBL592043
Indication Discovery agent Investigative [1587926]
Formula
C17H11F3O3
Canonical SMILES
Oc1ccc2C(=C(Cc3ccccc3)C(=O)Oc2c1)C(F)(F)F
InChI
InChI=1S/C17H11F3O3/c18-17(19,20)15-12-7-6-11(21)9-14(12)23-16(22)13(15)8-10-4-2-1-3-5-10/h1-7,9,21H,8H2
InChIKey
BBWVBLPWIQCZOJ-UHFFFAOYSA-N
Target and Pathway
Target(s) Estrogen receptor Target Info [1587926]
mRNA of androgen receptor Target Info [1587926]
KEGG Pathway Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Proteoglycans in cancerhsa04114:Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway FSH Signaling Pathway
EGFR1 Signaling Pathway
RANKL Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
Plasma membrane estrogen receptor signaling
LKB1 signaling events
Regulation of Telomerase
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-alpha and p38-beta
FOXA1 transcription factor networksmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Estrogen signaling pathway
Nuclear Receptors Meta-Pathway
Estrogen Receptor Pathway
Signaling by ERBB4
JAK/STAT
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Integrated Breast Cancer Pathway
Nuclear ReceptorsWP706:SIDS Susceptibility Pathways
Prostate Cancer
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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