Drug Information
| Drug General Information | |||||
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| Drug ID |
DX9K4I
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| Drug Name |
(3R,5S)-5-((4-(1-(2,5-difluorobenzyl)-1H-indazol-5-ylamino)thieno[3,2-d]pyrimidin-6-yl)ethynyl)pyrrolidin-3-yl morpholine-4-carboxylate
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| Synonyms |
CHEMBL500072
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C31H27F2N7O3S
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| Canonical SMILES |
Fc1ccc(F)c(Cn2ncc3cc(Nc4ncnc5cc(C#C[C@@H]6C[C@H](CN6)OC(=O)N7CCOCC7)sc45)ccc23)c1
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| InChI |
InChI=1S/C31H27F2N7O3S/c32-21-1-5-26(33)20(11-21)17-40-28-6-3-23(12-19(28)15-37-40)38-30-29-27(35-18-36-30)14-25(44-29)4-2-22-13-24(16-34-22)43-31(41)39-7-9-42-10-8-39/h1,3,5-6,11-12,14-15,18,22,24,34H,7-10,13,16-17H2,(H,35,36,38)/t22-,24-/m1/s1
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| InChIKey |
HRADRJGXRLBLGD-ISKFKSNPSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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