Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DX9OPU
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| Drug Name |
N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-6-methyl-5-(4-((2-(methylsulfonyl)ethylamino)methyl)styryl)pyrimidin-4-amine
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| Synonyms |
CHEMBL1934631
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C30H30ClFN4O3S
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| Canonical SMILES |
Cc1ncnc(Nc2ccc(OCc3cccc(F)c3)c(Cl)c2)c1\\C=C\\c4ccc(CNCCS(=O)(=O)C)cc4
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| InChI |
InChI=1S/C30H30ClFN4O3S/c1-21-27(12-10-22-6-8-23(9-7-22)18-33-14-15-40(2,37)38)30(35-20-34-21)36-26-11-13-29(28(31)17-26)39-19-24-4-3-5-25(32)16-24/h3-13,16-17,20,33H,14-15,18-19H2,1-2H3,(H,34,35,36)/b12-10+
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| InChIKey |
BLLJPLGCOYWICB-ZRDIBKRKSA-N
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| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
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