Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXB6UR
|
||||
| Drug Name |
1-{(E)-3-[4-(4-Benzyloxy-3-chloro-phenylamino)-3-cyano-7-ethoxy-quinolin-6-ylcarbamoyl]-allyl}-aziridine-2-carboxylic acid methyl ester
|
||||
| Synonyms |
CHEMBL359660
|
||||
| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C33H30ClN5O5
|
||||
| Canonical SMILES |
CCOc1cc2ncc(C#N)c(Nc3ccc(OCc4ccccc4)c(Cl)c3)c2cc1NC(=O)\\C=C\\CN5CC5C(=O)OC
|
||||
| InChI |
InChI=1S/C33H30ClN5O5/c1-3-43-30-16-26-24(15-27(30)38-31(40)10-7-13-39-19-28(39)33(41)42-2)32(22(17-35)18-36-26)37-23-11-12-29(25(34)14-23)44-20-21-8-5-4-6-9-21/h4-12,14-16,18,28H,3,13,19-20H2,1-2H3,(H,36,37)(H,38,40)/b10-7+
|
||||
| InChIKey |
UCDGCUOHOAAMOX-JXMROGBWSA-N
|
||||
| Target and Pathway | |||||
| Target(s) | Epidermal growth factor receptor III | Target Info | [1587926] | ||
| Receptor protein-tyrosine kinase erbB-2 | Target Info | [1587926] | |||
| KEGG Pathway | ErbB signaling pathway | ||||
| Calcium signaling pathway | |||||
| HIF-1 signaling pathway | |||||
| Focal adhesion | |||||
| Adherens junction | |||||
| Pathways in cancer | |||||
| Proteoglycans in cancer | |||||
| MicroRNAs in cancer | |||||
| Pancreatic cancer | |||||
| Endometrial cancer | |||||
| Prostate cancer | |||||
| Bladder cancer | |||||
| Non-small cell lung cancer | |||||
| Central carbon metabolism in cancer | |||||
| NetPath Pathway | TCR Signaling Pathway | ||||
| PANTHER Pathway | Cadherin signaling pathway | ||||
| EGF receptor signaling pathway | |||||
| PathWhiz Pathway | Phosphatidylinositol Phosphate Metabolism | ||||
| WikiPathways | DNA Damage Response (only ATM dependent) | ||||
| ErbB Signaling Pathway | |||||
| EGF/EGFR Signaling Pathway | |||||
| Focal Adhesion | |||||
| Extracellular vesicle-mediated signaling in recipient cells | |||||
| Bladder Cancer | |||||
| Signaling by ERBB2 | |||||
| Integrated Pancreatic Cancer Pathway | |||||
| Signaling Pathways in Glioblastoma | |||||
| Leptin signaling pathway | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| Semaphorin interactions | |||||
| References | |||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.