Drug Information

Drug General Information
Drug ID
DXE1O6
Drug Name
3-{4-[7-(1H-Indol-5-ylamino)-thieno[3,2-b]pyridin-2-yl]-benzylamino}-propan-1-ol
Synonyms
CHEMBL77452
Indication Discovery agent Investigative [1587926]
Formula
C25H24N4OS
Canonical SMILES
OCCCNCc1ccc(cc1)c2cc3nccc(Nc4ccc5[nH]ccc5c4)c3s2
InChI
InChI=1S/C25H24N4OS/c30-13-1-10-26-16-17-2-4-18(5-3-17)24-15-23-25(31-24)22(9-12-28-23)29-20-6-7-21-19(14-20)8-11-27-21/h2-9,11-12,14-15,26-27,30H,1,10,13,16H2,(H,28,29)
InChIKey
MDSJWBBQCSEPDO-UHFFFAOYSA-N
Target and Pathway
Target(s) Epidermal growth factor receptor III Target Info [1587926]
Vascular endothelial growth factor receptor 1 Target Info [1587926]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Signaling by VEGF
Angiogenesis
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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