Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXF74T
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| Drug Name |
(4-Chloro-2-trifluoromethyl-phenyl)-carbamic acid (3R)-2-oxo-1-{[4-oxo-(1S)-1-phenethylpent-2-enylcarbamoyl]-methyl}-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethylester
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| Synonyms |
CHEMBL450459
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C39H34ClF3N4O5
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| Canonical SMILES |
CC(=O)\\C=C\\[C@H](CCc1ccccc1)NC(=O)CN2C(=O)[C@@H](COC(=O)Nc3ccc(Cl)cc3C(F)(F)F)N=C(c4ccccc4)c5ccccc25
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| InChI |
InChI=1S/C39H34ClF3N4O5/c1-25(48)16-19-29(20-17-26-10-4-2-5-11-26)44-35(49)23-47-34-15-9-8-14-30(34)36(27-12-6-3-7-13-27)45-33(37(47)50)24-52-38(51)46-32-21-18-28(40)22-31(32)39(41,42)43/h2-16,18-19,21-22,29,33H,17,20,23-24H2,1H3,(H,44,49)(H,46,51)/b19-16+/t29-,33-/m1/s1
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| InChIKey |
FOKNRHPLVHWJHK-SFTMMTGKSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
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