Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
DXGM3N
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| Drug Name |
(4-chloro-2-trifluoromethyl-phenyl)-carbamic acid 1-{[3-benzenesulfonyl-(1S)-1-phenethyl-allylcarbamoyl]-methyl}-(3R)-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-ylmethylester
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| Synonyms |
CHEMBL402455
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| Indication | Discovery agent | Investigative | [1587926] | ||
| Formula |
C43H36ClF3N4O6S
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| Canonical SMILES |
FC(F)(F)c1cc(Cl)ccc1NC(=O)OC[C@H]2N=C(c3ccccc3)c4ccccc4N(CC(=O)N[C@@H](CCc5ccccc5)\\C=C\\S(=O)(=O)c6ccccc6)C2=O
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| InChI |
InChI=1S/C43H36ClF3N4O6S/c44-31-21-23-36(35(26-31)43(45,46)47)50-42(54)57-28-37-41(53)51(38-19-11-10-18-34(38)40(49-37)30-14-6-2-7-15-30)27-39(52)48-32(22-20-29-12-4-1-5-13-29)24-25-58(55,56)33-16-8-3-9-17-33/h1-19,21,23-26,32,37H,20,22,27-28H2,(H,48,52)(H,50,54)/b25-24+/t32-,37+/m0/s1
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| InChIKey |
NJRZPPVQNUUPRV-JZPORDAXSA-N
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| Target and Pathway | |||||
| Target(s) | Cathepsin L | Target Info | [1587926] | ||
| Cathepsin B | Target Info | [1587926] | |||
| Reactome | Endosomal/Vacuolar pathway | ||||
| Collagen degradation | |||||
| Degradation of the extracellular matrix | |||||
| Trafficking and processing of endosomal TLR | |||||
| Assembly of collagen fibrils and other multimeric structures | |||||
| MHC class II antigen presentationR-HSA-1442490:Collagen degradation | |||||
| MHC class II antigen presentation | |||||
| WikiPathways | Primary Focal Segmental Glomerulosclerosis FSGS | ||||
| References | |||||
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