Drug Information

Drug General Information
Drug ID
DXJ8NO
Drug Name
(5S,6S)-5-(hydroxycarbamoyl)-6-((R)-3-phenylpyrrolidine-1-carbonyl)piperidin-3-yl pyrrolidine-1-carboxylate hydrochloride
Synonyms
CHEMBL1204013
Indication Discovery agent Investigative [1587926]
Formula
C22H31ClN4O5
Canonical SMILES
Cl.ONC(=O)[C@H]1CC(CN[C@@H]1C(=O)N2CC[C@@H](C2)c3ccccc3)OC(=O)N4CCCC4
InChI
InChI=1S/C22H30N4O5.ClH/c27-20(24-30)18-12-17(31-22(29)25-9-4-5-10-25)13-23-19(18)21(28)26-11-8-16(14-26)15-6-2-1-3-7-15;/h1-3,6-7,16-19,23,30H,4-5,8-14H2,(H,24,27);1H/t16-,17?,18-,19-;/m0./s1
InChIKey
RUFCUNSVBIYRLT-CPLNNKCJSA-N
Target and Pathway
Target(s) 72 kDa type IV collagenase Target Info [1587926]
Receptor protein-tyrosine kinase erbB-2 Target Info [1587926]
KEGG Pathway Leukocyte transendothelial migration
GnRH signaling pathway
Estrogen signaling pathway
Pathways in cancer
Proteoglycans in cancer
Bladder cancerhsa04012:ErbB signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Focal adhesion
Adherens junction
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Bladder cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
NetPath Pathway Leptin Signaling Pathway
TCR Signaling Pathway
ID Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Alzheimer disease-presenilin pathwayP00012:Cadherin signaling pathway
EGF receptor signaling pathway
Pathway Interaction Database LPA receptor mediated events
Plasma membrane estrogen receptor signaling
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Direct p53 effectors
amb2 Integrin signaling
ATF-2 transcription factor network
FOXM1 transcription factor network
Regulation of nuclear beta catenin signaling and target gene transcription
Syndecan-2-mediated signaling eventserbb4_pathway:ErbB4 signaling events
ErbB2/ErbB3 signaling events
ErbB receptor signaling network
a6b1 and a6b4 Integrin signaling
Validated targets of C-MYC transcriptional repression
PathWhiz Pathway Phosphatidylinositol Phosphate Metabolism
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
EPH-ephrin mediated repulsion of cellsR-HSA-1250196:SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
WikiPathways Activation of Matrix Metalloproteinases
AGE/RAGE pathway
Matrix MetalloproteinasesWP710:DNA Damage Response (only ATM dependent)
ErbB Signaling Pathway
EGF/EGFR Signaling Pathway
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Bladder Cancer
Signaling by ERBB2
Integrated Pancreatic Cancer Pathway
Signaling Pathways in Glioblastoma
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
Semaphorin interactions
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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