Drug Information

Drug General Information
Drug ID
DXQ0LT
Drug Name
4-Methoxy-benzenesulfonic acid 3-hydroxycarbamoyl-2-(4-methoxy-benzenesulfonyl)-1,2,3,4-tetrahydro-isoquinolin-7-yl ester
Synonyms
CHEMBL138643
Indication Discovery agent Investigative [1587926]
Formula
C24H24N2O9S2
Canonical SMILES
COc1ccc(cc1)S(=O)(=O)Oc2ccc3CC(N(Cc3c2)S(=O)(=O)c4ccc(OC)cc4)C(=O)NO
InChI
InChI=1S/C24H24N2O9S2/c1-33-18-5-9-21(10-6-18)36(29,30)26-15-17-13-20(4-3-16(17)14-23(26)24(27)25-28)35-37(31,32)22-11-7-19(34-2)8-12-22/h3-13,23,28H,14-15H2,1-2H3,(H,25,27)
InChIKey
BXZZUNDHINECCH-UHFFFAOYSA-N
Target and Pathway
Target(s) Stromelysin-1 Target Info [1587926]
Neutrophil collagenase Target Info [1587926]
KEGG Pathway TNF signaling pathway
Transcriptional misregulation in cancer
Rheumatoid arthritis
NetPath Pathway IL1 Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Plasminogen activating cascade
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome Collagen degradation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Assembly of collagen fibrils and other multimeric structures
EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
WikiPathways Activation of Matrix Metalloproteinases
Gastrin-CREB signalling pathway via PKC and MAPK
Oncostatin M Signaling Pathway
Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
Matrix Metalloproteinases
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.