Drug Information

Drug General Information
Drug ID
DXX01J
Drug Name
3-(1H-Indol-3-yl)-2-methyl-2-(3-naphthalen-2-yl-ureido)-N-phenethyl-propionamide
Synonyms
CHEMBL99065
Indication Discovery agent Investigative [1587926]
Formula
C31H30N4O2
Canonical SMILES
CC(Cc1c[nH]c2ccccc12)(NC(=O)Nc3ccc4ccccc4c3)C(=O)NCCc5ccccc5
InChI
InChI=1S/C31H30N4O2/c1-31(20-25-21-33-28-14-8-7-13-27(25)28,29(36)32-18-17-22-9-3-2-4-10-22)35-30(37)34-26-16-15-23-11-5-6-12-24(23)19-26/h2-16,19,21,33H,17-18,20H2,1H3,(H,32,36)(H2,34,35,37)
InChIKey
VEJKRPAUHOZTNE-UHFFFAOYSA-N
Target and Pathway
Target(s) Gastrin/cholecystokinin type B receptor Target Info [1587926]
Cholecystokinin receptor type A Target Info [1587926]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretionhsa04020:Calcium signaling pathway
Insulin secretion
Pancreatic secretion
PANTHER Pathway CCKR signaling map ST
PathWhiz Pathway Gastric Acid Production
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-375276:Peptide ligand-binding receptors
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
References
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017
Ref 1587926URL: https://www.ebi.ac.uk/chembl/ The ChEMBL database in 2017

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