Drug Information

Drug General Information
Drug ID
D00FJT
Former ID
DIB018130
Drug Name
[11C]volinanserin
Synonyms
[11C]M100907 (PET ligand); [11C]MDL100907
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540222]
Structure
Download
2D MOL
Formula
C22H28FNO3
InChI
InChI=1S/C22H28FNO3/c1-26-20-5-3-4-19(22(20)27-2)21(25)17-11-14-24(15-12-17)13-10-16-6-8-18(23)9-7-16/h3-9,17,21,25H,10-15H2,1-2H3/t21-/m1/s1/i1-1
InChIKey
HXTGXYRHXAGCFP-AVUPQLEMSA-N
PubChem Compound ID
449851
PubChem Substance ID
230, 1611, 10300430, 15917387, 36891345, 80773859, 104641704, 135651096, 175427548, 198965204
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [525893]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 540222(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3249).
Ref 525893Autoradiographic localization of 5-HT(2A) receptors in the human brain using [(3)H]M100907 and [(11)C]M100907. Synapse. 2000 Dec 15;38(4):421-31.

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