Drug General Information
Drug ID
D00HTY
Former ID
DIB018020
Drug Name
PGF2alpha
Synonyms
Amoglandin; Cerviprost; Cyclosin; Enzaprost; Panacelan; prostaglandin F2alpha
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Clinical trial [532003]
Structure
Download
2D MOL
Formula
C20H34O5
InChI
InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
InChIKey
PXGPLTODNUVGFL-YNNPMVKQSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Prostaglandin F2-alpha receptor Target Info Agonist [526505]
Putative G-protein coupled receptor 44 Target Info Agonist [526611]
Thromboxane A2 receptor Target Info Agonist [525673]
Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [534595]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534478]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [525571]
Prostaglandin E2 receptor, EP4 subtype Target Info Agonist [534595]
Prostaglandin D2 receptor Target Info Agonist [525673]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interaction
Platelet activationhsa04020:Calcium signaling pathway
Pathways in cancerhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancerhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling PathwayNetPath_25:FSH Signaling Pathway
IL2 Signaling Pathway
IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (q) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
Vitamin D Receptor Pathway
References
Ref 532003Stereocontrolled organocatalytic synthesis of prostaglandin PGF2alpha in seven steps. Nature. 2012 Sep 13;489(7415):278-81.
Ref 525571Importance of the extracellular domain for prostaglandin EP(2) receptor function. Mol Pharmacol. 1999 Sep;56(3):545-51.
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 526505Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. Biochem J. 2003 Apr 15;371(Pt 2):443-9.
Ref 526611Expression and molecular pharmacology of the mouse CRTH2 receptor. J Pharmacol Exp Ther. 2003 Aug;306(2):463-70. Epub 2003 Apr 29.
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.
Ref 534595Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes. Eur J Pharmacol. 1997 Dec 11;340(2-3):227-41.

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