Drug General Information
Drug ID	D00LWS
Former ID	DIB015773
Drug Name	Ataprost
Synonyms	ONO-41483; OP-41483
Drug Type	Small molecular drug
Indication	Asthma [ICD10:J45]		Discontinued in Phase 3	[545086]
Company	Ono Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C21H32O4
Canonical SMILES	[C@H]12[C@H](C[C@H]([C@@H]1/C=C/[C@H](C1CCCC1)O)O)C/C(=<br />C\CCCC(=O)O)/C2
CAS Number	CAS 83997-19-7
PubChem Compound ID	6436122
Target and Pathway
Target(s)	Prostacyclin receptor	Target Info	Modulator	[533933]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Platelet activation
Pathway Interaction Database	Thromboxane A2 receptor signaling
PathWhiz Pathway	Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome	Prostanoid ligand receptors
	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	Endothelin Pathways
	Platelet homeostasis
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545086	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002073)
Ref 533933	Pharmacokinetics of intravenous ataprost alfadex, a new prostaglandin I2 analog in healthy volunteers. Int J Clin Pharmacol Ther Toxicol. 1993 Aug;31(8):373-5.

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