Drug Information

Drug General Information
Drug ID
D00PEJ
Former ID
DNC007351
Drug Name
1-guanidino-N-phenyl-7-isoquinolinesulphonamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528796]
Structure
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2D MOL

3D MOL
Formula
C16H15N5O2S
Canonical SMILES
C1=CC=C(C=C1)NS(=O)(=O)C2=CC3=C(C=C2)C=CN=C3N=C(N)N
InChI
1S/C16H15N5O2S/c17-16(18)20-15-14-10-13(7-6-11(14)8-9-19-15)24(22,23)21-12-4-2-1-3-5-12/h1-10,21H,(H4,17,18,19,20)
InChIKey
NNEJXIJKGKRBBF-UHFFFAOYSA-N
PubChem Compound ID
16658631
Target and Pathway
Target(s) Plasminogen Target Info Inhibitor [528796]
Tissue-type plasminogen activator Target Info Inhibitor [528796]
Urokinase-type plasminogen activator Target Info Inhibitor [528796]
KEGG Pathway Neuroactive ligand-receptor interaction
Complement and coagulation cascades
Staphylococcus aureus infection
Influenza Ahsa04610:Complement and coagulation cascades
Transcriptional misregulation in cancerhsa04064:NF-kappa B signaling pathway
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
NetPath Pathway IL5 Signaling PathwayNetPath_14:IL2 Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Blood coagulation
Plasminogen activating cascadeP00011:Blood coagulation
Plasminogen activating cascade
CCKR signaling map ST
Pathway Interaction Database Angiopoietin receptor Tie2-mediated signaling
p75(NTR)-mediated signaling
amb2 Integrin signaling
Syndecan-4-mediated signaling events
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingamb2_neutrophils_pathway:amb2 Integrin signaling
Beta2 integrin cell surface interactionsintegrin1_pathway:Beta1 integrin cell surface interactions
E2F transcription factor network
Beta3 integrin cell surface interactions
Osteopontin-mediated events
Validated transcriptional targets of AP1 family members Fra1 and Fra2
ATF-2 transcription factor network
AP-1 transcription factor network
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Beta5 beta6 beta7 and beta8 integrin cell surface interactions
FGF signaling pathway
PathWhiz Pathway CoagulationPW000562:Coagulation
Reactome Platelet degranulation
Degradation of the extracellular matrix
Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Dissolution of Fibrin ClotR-HSA-75205:Dissolution of Fibrin ClotR-HSA-75205:Dissolution of Fibrin Clot
WikiPathways Complement and Coagulation Cascades
Human Complement System
Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activation of Matrix Metalloproteinases
Blood Clotting Cascade
Dissolution of Fibrin Clot
Folate Metabolism
Vitamin B12 Metabolism
Selenium Micronutrient NetworkWP615:Senescence and Autophagy in Cancer
Endochondral Ossification
Selenium Micronutrient NetworkWP710:DNA Damage Response (only ATM dependent)
Senescence and Autophagy in Cancer
Wnt Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Osteopontin Signaling
References
Ref 528796J Med Chem. 2007 May 17;50(10):2341-51. Epub 2007 Apr 21.Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.
Ref 528796J Med Chem. 2007 May 17;50(10):2341-51. Epub 2007 Apr 21.Selective urokinase-type plasminogen activator inhibitors. 4. 1-(7-sulfonamidoisoquinolinyl)guanidines.

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