Drug Information

Drug General Information
Drug ID
D00PXQ
Former ID
DPR000043
Drug Name
Fananserin
Synonyms
RP 62203; Fananserin [USAN:INN]; RP-62203; Fananserin (USAN/INN); 2-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-2H-naphth(1,8-cd)isothiazole 1,1-dioxide; 2-(3-(4-(p-Fluorophenyl)-1-piperazinyl)propyl)-2H-naphth(1,8-cd)isothiazole 1,1-dioxide; 2H-Naphth(1,8-cd)isothiazole, 2-(3-(4-(4-fluorophenyl)-1-piperazinyl)propyl)-, 1,1-dioxide
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Terminated [536463], [540837]
Company
Sanofi-Aventis
Structure
Download
2D MOL

3D MOL
Formula
C23H24FN3O2S
InChI
InChI=1S/C23H24FN3O2S/c24-19-8-10-20(11-9-19)26-16-14-25(15-17-26)12-3-13-27-21-6-1-4-18-5-2-7-22(23(18)21)30(27,28)29/h1-2,4-11H,3,12-17H2
InChIKey
VGIGHGMPMUCLIQ-UHFFFAOYSA-N
CAS Number
CAS 127625-29-0
PubChem Compound ID
60785
PubChem Substance ID
8187052, 14856245, 43118132, 47205811, 50064308, 50112947, 57314111, 78566174, 85212007, 85788217, 103922972, 104321638, 129471014, 134339513, 135018988, 135698206, 137237442, 140010545, 140173976, 144206140, 160703995, 162023484, 163124146, 170466120, 178100286, 178102086, 179149761, 198976575, 204372620, 224932293, 226676066, 241376050, 249617645, 250071166, 252156679
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Antagonist [536463]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.
Ref 540837(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5434).
Ref 536463The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22. Epub 2007 Jul 31.

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