Drug Information

Drug General Information
Drug ID
D00WMV
Former ID
DIB021111
Drug Name
UCL1684
Synonyms
UCL-1684
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539467]
Structure
Download
2D MOL
Formula
C34H30N4+2
InChI
InChI=1S/C34H28N4/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31/h1-20H,21-24H2/p+2
InChIKey
HZWVJPDDZQOYGA-UHFFFAOYSA-P
PubChem Compound ID
656733
PubChem Substance ID
854028, 7980861, 9268119, 53552701, 57408413, 103342144, 103957525, 113528165, 135651295, 135727697, 142572714, 143344345, 223442170, 242091045, 242726802, 247678661
Target and Pathway
Target(s) KCa2.1 Target Info Blocker (channel blocker) [530822]
KCa2.2 Target Info Blocker (channel blocker) [525707]
KCa2.3 Target Info Blocker (channel blocker) [526131]
References
Ref 539467(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2320).
Ref 525707Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9.
Ref 526131SK3 is an important component of K(+) channels mediating the afterhyperpolarization in cultured rat SCG neurones. J Physiol. 2001 Sep 1;535(Pt 2):323-34.
Ref 530822Small conductance calcium-activated potassium channels: from structure to function. Prog Neurobiol. 2010 Jul;91(3):242-55.

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