Drug Information

Drug General Information
Drug ID
D00YNW
Former ID
DIB020302
Drug Name
M826
Synonyms
compound 4sx
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527416]
Structure
Download
2D MOL
Formula
C28H45N7O6
InChI
InChI=1S/C28H45N7O6/c1-8-10-11-12-13-34(7)16-22(36)19(14-24(37)38)30-26(39)21(9-2)35-17-23(28(4,5)6)31-25(27(35)40)29-15-20-18(3)32-41-33-20/h17,19,21H,8-16H2,1-7H3,(H,29,31)(H,30,39)(H,37,38)
InChIKey
XIMITGPWYYFUQF-UHFFFAOYSA-N
PubChem Compound ID
9851134
PubChem Substance ID
14813235, 24146931, 45273458, 76745557, 137184257, 142172140, 242096640, 247690259, 252166854
Target and Pathway
Target(s) Caspase 5 Target Info Inhibitor [527416]
Interleukin-1 beta convertase Target Info Inhibitor [527416]
Apopain Target Info Inhibitor [527416]
Caspase 7 Target Info Inhibitor [527416]
Caspase 4 Target Info Inhibitor [527416]
KEGG Pathway NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Amyotrophic lateral sclerosis (ALS)
Salmonella infection
Pertussis
Legionellosis
Influenza Ahsa04010:MAPK signaling pathway
p53 signaling pathway
Apoptosis
Natural killer cell mediated cytotoxicity
TNF signaling pathway
Serotonergic synapse
Non-alcoholic fatty liver disease (NAFLD)
Alzheimer's disease
Parkinson's disease
Huntington's disease
Epithelial cell signaling in Helicobacter pylori infection
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Herpes simplex infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Viral myocarditis
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling Pathway
IL4 Signaling Pathway
PANTHER Pathway Apoptosis signaling pathway
FAS signaling pathway
Huntington disease
CCKR signaling map ST
Pathway Interaction Database IL1-mediated signaling events
Direct p53 effectors
IFN-gamma pathway
Cellular roles of Anthrax toxinlysophospholipid_pathway:LPA receptor mediated events
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
FAS (CD95) signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Posttranslational regulation of adherens junction stability and dissassembly
p75(NTR)-mediated signaling
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Caspase Cascade in Apoptosis
Syndecan-2-mediated signaling events
Reactome NOD1/2 Signaling Pathway
Interleukin-1 processing
The NLRP3 inflammasomeR-HSA-111463:SMAC binds to IAPs
SMAC-mediated dissociation of IAP:caspase complexes
Apoptotic cleavage of cellular proteins
Degradation of the extracellular matrix
NADE modulates death signalling
Activation of DNA fragmentation factor
Caspase-mediated cleavage of cytoskeletal proteins
WikiPathways MAPK Signaling Pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
Apoptosis
Amyotrophic lateral sclerosis (ALS)
Parkin-Ubiquitin Proteasomal System pathway
Interleukin-1 processing
Apoptosis Modulation and Signaling
NOD pathwayWP707:DNA Damage Response
SIDS Susceptibility Pathways
Apoptosis Modulation by HSP70
Copper homeostasis
FAS pathway and Stress induction of HSP regulation
Signaling by Hippo
Spinal Cord Injury
BDNF signaling pathway
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Parkinsons Disease Pathway
Corticotropin-releasing hormone
Allograft Rejection
AGE/RAGE pathway
TNF alpha Signaling Pathway
Prostate Cancer
Alzheimers Disease
TWEAK Signaling Pathway
Integrated Breast Cancer Pathway
Signalling by NGF
Integrated Cancer pathway
Regulation of Apoptosis
Intrinsic Pathway for Apoptosis
Apoptotic execution phase
miRNA Regulation of DNA Damage Response
References
Ref 527416Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80.
Ref 527416Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett. 2005 Feb 15;15(4):1173-80.

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