Drug Information

Drug General Information
Drug ID
D01EWC
Former ID
DIB001334
Drug Name
CR-2991
Synonyms
Quinazoline alpha1 adrenoceptor antagonist (hypertension, prostatic hyperplasia), Rottapharm
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Terminated [547727]
Company
Rottapharm Madaus
Target and Pathway
Target(s) Alpha-1D adrenergic receptor Target Info Antagonist [550128]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Salivary secretion
NetPath Pathway IL2 Signaling Pathway
Reactome Adrenoceptors
G alpha (q) signalling events
G alpha (12/13) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 547727Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018844)
Ref 550128WO patent application no. 2006,1244,90, Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia.

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