Drug Information

Drug General Information
Drug ID
D01JRD
Former ID
DIB018330
Drug Name
[3H]mazindol
Synonyms
[3H]-mazindol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467831]
Structure
Download
2D MOL
Formula
C16H13ClN2O
InChI
InChI=1S/C16H13ClN2O/c17-12-7-5-11(6-8-12)16(20)14-4-2-1-3-13(14)15-18-9-10-19(15)16/h1-8,20H,9-10H2
InChIKey
ZPXSCAKFGYXMGA-UHFFFAOYSA-N
PubChem Compound ID
4020
PubChem Substance ID
5663207, 7847433, 7979864, 8152518, 10514045, 14897762, 24896596, 29223131, 46509094, 48416196, 49978900, 51064091, 53789697, 57322096, 85174591, 92711740, 99431540, 103206445, 103856500, 103919017, 104305195, 125345244, 126630564, 126665962, 129938107, 131305866, 134338010, 134993905, 136949640, 137154621, 143038295, 152034992, 152258665, 160647502, 160830559, 160963924, 163094692, 163393871, 164228469, 164814279, 178101312, 178101499, 179116764, 186022457, 198993257, 204388874, 223664711, 224771980, 226415324, 241041015
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [527164]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 467831(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4591).
Ref 527164Binding of [3H]mazindol to cardiac norepinephrine transporters: kinetic and equilibrium studies. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jul;370(1):9-16. Epub 2004 Jul 22.

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