Drug Information

Drug General Information
Drug ID
D01MML
Former ID
DNCL002314
Drug Name
MLN9708
Synonyms
Ixazomib
Drug Type
Small molecular drug
Indication Multiple myeloma; Relapsed or refractory primary amyloidosis [ICD9: 203, 277.3; ICD10:C90, E85] Approved [524820], [543142]
Company
Millennium Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C14H19BCl2N2O4
InChI
InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1
InChIKey
MXAYKZJJDUDWDS-LBPRGKRZSA-N
PubChem Compound ID
25183872
PubChem Substance ID
57291607, 85029113, 104253504, 124757626, 124955652, 125164430, 135268985, 135626848, 136340279, 136348738, 136367593, 138100925, 144116241, 152134539, 162011779, 162037798, 162202726, 162773434, 163326535, 163347633, 163908014, 164193936, 164834143, 174007116, 174526063, 177748936, 184814067, 198939582, 203355961, 210274689, 210280323, 223389604, 229732516, 248181513, 249810660, 252110098, 252166660, 252213184, 252443130
Target and Pathway
Target(s) Proteasome Target Info Modulator [530730]
References
Ref 524820ClinicalTrials.gov (NCT02181413) A Study of Oral Ixazomib Citrate (MLN9708) Maintenance Therapy in Patients With Multiple Myeloma Following Autologous Stem Cell Transplant. U.S. National Institutes of Health.
Ref 543142(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8450).
Ref 530730Evaluation of the proteasome inhibitor MLN9708 in preclinical models of human cancer. Cancer Res. 2010 Mar 1;70(5):1970-80.

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