Drug Information

Drug General Information
Drug ID
D01XHU
Former ID
DIB003810
Drug Name
AN-207
Synonyms
D-26232; Doxorubicin-analog-[D-Lys(6)]LHRH conjugate, Tulane University/Zentaris
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Investigative [543648]
Company
Tulane University
Structure
Download
2D MOL

3D MOL
Formula
C95H121N19O26
Canonical SMILES
c12c(C(=O)c3c(C1=O)cccc3OC)c(c1c(c2O)C[C@](C[C@@H]1O[C@<br />H]1C[C@@H]([C@@H]([C@@H](O1)C)O)N1C=CCC1)(C(=O)COC(=O)C<br />CCC(=O)NCCCC[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1[C@H](<br />C(=O)NCC(=O)N)CCC1)CCCNC(=N)N)CC(C)C)NC(=O)[C@@H](NC(=O<br />)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)CC1<br />)Cc1nc[nH]c1)Cc1c[nH]c2c1cccc2)CO)Cc1ccc(cc1)O)O)O
CAS Number
CAS 179910-83-9
PubChem Compound ID
16197730
Target and Pathway
Target(s) Gonadotropin-releasing hormone receptor Target Info Inhibitor [543648]
KEGG Pathway Neuroactive ligand-receptor interaction
GnRH signaling pathway
NetPath Pathway IL1 Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Hormone ligand-binding receptors
G alpha (q) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 543648(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256).
Ref 543648(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 256).

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