Drug General Information
Drug ID
D02BBA
Former ID
DIB019822
Drug Name
EPZ005687
Synonyms
EPZ-005687; EPZ 005687
Drug Type
Small molecular drug
Indication Discovery agent Investigative [532062]
Structure
Download
2D MOL
Formula
C32H37N5O3
InChI
InChI=1S/C32H37N5O3/c1-21-15-22(2)35-32(39)28(21)18-33-31(38)27-16-25(17-30-29(27)19-34-37(30)26-5-3-4-6-26)24-9-7-23(8-10-24)20-36-11-13-40-14-12-36/h7-10,15-17,19,26H,3-6,11-14,18,20H2,1-2H3,(H,33,38)(H,35,39)
InChIKey
ZOIBZSZLMJDVDQ-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Enhancer of zeste homolog 2 Target Info Inhibitor [532062]
KEGG Pathway MicroRNAs in cancer
NetPath Pathway IL2 Signaling Pathway
Reactome PRC2 methylates histones and DNA
Oxidative Stress Induced Senescence
PKMTs methylate histone lysines
WikiPathways Interactome of polycomb repressive complex 2 (PRC2)
Endoderm Differentiation
Integrated Pancreatic Cancer Pathway
Histone Modifications
Cell Differentiation - meta
miRs in Muscle Cell Differentiation
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
References
Ref 532062A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov;8(11):890-6.
Ref 532062A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nat Chem Biol. 2012 Nov;8(11):890-6.

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