Drug Information

Drug General Information
Drug ID
D02BIK
Former ID
DNC000248
Drug Name
AR-534
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537221]
Structure
Download
2D MOL

3D MOL
Formula
C19H20N6O4S
Canonical SMILES
COCCNS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(C(=N2)C(=O)NC3=CN=CC<br />=C3)N
InChI
1S/C19H20N6O4S/c1-29-10-9-23-30(27,28)15-6-4-13(5-7-15)16-12-22-18(20)17(25-16)19(26)24-14-3-2-8-21-11-14/h2-8,11-12,23H,9-10H2,1H3,(H2,20,22)(H,24,26)
InChIKey
OMGQIHJJEYTELG-UHFFFAOYSA-N
PubChem Compound ID
56603751
PubChem Substance ID
134339723, 163335097, 163346770, 163474230
Target and Pathway
Target(s) Glycogen synthase kinase-3 Target Info Inhibitor [537221]
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Insulin/IGF pathway-protein kinase B signaling cascade
PDGF signaling pathway
Ras Pathway
Pathway Interaction Database Degradation of beta catenin
Canonical Wnt signaling pathway
FOXM1 transcription factor network
Class I PI3K signaling events mediated by Akt
Reactome AKT phosphorylates targets in the cytosol
XBP1(S) activates chaperone genes
Constitutive Signaling by AKT1 E17K in Cancer
References
Ref 537221A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95. doi: 10.1172/JCI37537. Epub 2009 Apr 13.
Ref 537221A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest. 2009 May;119(5):1382-95. doi: 10.1172/JCI37537. Epub 2009 Apr 13.

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