Drug Information

Drug General Information
Drug ID
D02FQG
Former ID
DIB020779
Drug Name
pyrrolidine MCHR1 antagonist 1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531400]
Structure
Download
2D MOL
Formula
C26H33ClN2O4
InChI
InChI=1S/C26H33ClN2O4/c1-32-23-7-5-19(6-8-23)24-18-29(12-9-26(31)10-13-33-14-11-26)17-20(24)15-25(30)28-22-4-2-3-21(27)16-22/h2-8,16,20,24,31H,9-15,17-18H2,1H3,(H,28,30)/t20-,24+/m0/s1
InChIKey
OLINDOIRFAZHRH-GBXCKJPGSA-N
PubChem Compound ID
54579974
PubChem Substance ID
131271905, 131343138, 223366089
Target and Pathway
Target(s) Melanin-concentrating hormone receptor 1 Target Info Antagonist [531400]
KEGG Pathway Neuroactive ligand-receptor interaction
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 531400Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2460-7.
Ref 531400Novel pyrrolidine melanin-concentrating hormone receptor 1 antagonists with reduced hERG inhibition. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2460-7.

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