Drug General Information
Drug ID	D02HNE
Former ID	DNC008260
Drug Name	5-(2-(pyrrolidin-1-yl)ethyl)isothiazole
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529212]
Structure		Download 2D MOL 3D MOL
Formula	C9H14N2S
Canonical SMILES	C1CCN(C1)CCC2=CC=NS2
InChI	1S/C9H14N2S/c1-2-7-11(6-1)8-4-9-3-5-10-12-9/h3,5H,1-2,4,6-8H2
InChIKey	GRXWPIZSBSTAQX-UHFFFAOYSA-N
PubChem Compound ID	44456451
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Inhibitor	[529212]
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 529212	Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. Epub 2007 Oct 24.In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.
Ref 529212	Bioorg Med Chem Lett. 2008 Jan 1;18(1):355-9. Epub 2007 Oct 24.In vitro SAR of pyrrolidine-containing histamine H3 receptor antagonists: trends across multiple chemical series.

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