Drug Information

Drug General Information
Drug ID
D02JEZ
Former ID
DNC000103
Drug Name
7-hydroxycoumarin
Drug Type
Small molecular drug
Indication Discovery agent Investigative [535287]
Structure
Download
2D MOL

3D MOL
Formula
C9H6O3
Canonical SMILES
C1=CC(=CC2=C1C=CC(=O)O2)O
InChI
1S/C9H6O3/c10-7-3-1-6-2-4-9(11)12-8(6)5-7/h1-5,10H
InChIKey
ORHBXUUXSCNDEV-UHFFFAOYSA-N
PubChem Compound ID
5281426
PubChem Substance ID
11506, 82592, 589071, 601312, 894672, 3133441, 6654657, 8138035, 8144499, 8616620, 10538273, 11371682, 11406039, 11485819, 11489778, 11490567, 11537968, 15321753, 24889947, 24895162, 26613209, 26679323, 26749818, 29204654, 35037624, 35037687, 36026715, 37041382, 39290237, 47365382, 47365383, 48334686, 49743161, 49835726, 49956270, 50123357, 50123358, 51074934, 53705440, 53789635, 57358161, 57391252, 57653583, 57968425, 81041515, 81092928, 85086760, 85789232, 85789383, 87550949
Target and Pathway
Target(s) G1/S-specific cyclin D1 Target Info Inhibitor [535287]
KEGG Pathway FoxO signaling pathway
Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Wnt signaling pathway
Hippo signaling pathway
Focal adhesion
Jak-STAT signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Hepatitis B
Measles
HTLV-I infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Viral myocarditis
NetPath Pathway TCR Signaling Pathway
IL2 Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Notch Signaling Pathway
Wnt Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Wnt signaling pathway
CCKR signaling map ST
Pathway Interaction Database Notch signaling pathway
Coregulation of Androgen receptor activity
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Presenilin action in Notch and Wnt signaling
Integrin-linked kinase signaling
Regulation of Telomerase
E-cadherin signaling in the nascent adherens junction
ATF-2 transcription factor network
AP-1 transcription factor network
FOXM1 transcription factor network
Neurotrophic factor-mediated Trk receptor signaling
C-MYB transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-gamma and p38-delta
Regulation of nuclear beta catenin signaling and target gene transcription
Validated targets of C-MYC transcriptional repression
Trk receptor signaling mediated by PI3K and PLC-gamma
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinase
Reactome Pre-NOTCH Transcription and Translation
RMTs methylate histone arginines
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1
WikiPathways DNA Damage Response (only ATM dependent)
DNA Damage Response
Notch Signaling Pathway
G1 to S cell cycle control
Wnt Signaling Pathway and Pluripotency
TGF beta Signaling Pathway
Wnt Signaling Pathway Netpath
Copper homeostasis
Focal Adhesion
PPAR Alpha Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Bladder Cancer
Pre-NOTCH Expression and Processing
S Phase
Polycystic Kidney Disease Pathway
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
IL-7 Signaling Pathway
Leptin signaling pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Integrated Breast Cancer Pathway
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
Androgen receptor signaling pathway
References
Ref 535287Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin. Lung Cancer. 2001 Nov;34(2):185-94.
Ref 535287Decrease of cyclin D1 in the human lung adenocarcinoma cell line A-427 by 7-hydroxycoumarin. Lung Cancer. 2001 Nov;34(2):185-94.

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