Drug Information

Drug General Information
Drug ID
D02NIP
Former ID
DIB014171
Drug Name
ITASETRON
Synonyms
DAU6215CL; DAU-6215; Itasetron < Rec INN; U-98079A; N-(endo-8-Methyl-8-azabicyclo[3.2.1]oct-3-yl)-2-oxo-2,3-dihydro-1H-benzimidazole-1-carboxamide; 2-Oxo-N-(1alphaH,5alphaH-tropan-3alpha-yl)-1-benzimidazoline-1-carboxamide
Drug Type
Small molecular drug
Indication Nausea [ICD10:R11] Phase 1 [524948]
Structure
Download
2D MOL

3D MOL
Formula
C16H20N4O2
Canonical SMILES
CN1[C@@H]2CC[C@H]1C[C@H](C2)NC(=O)N3C(=O)Nc4ccccc34
InChI
1S/C16H20N4O2/c1-19-11-6-7-12(19)9-10(8-11)17-15(21)20-14-5-3-2-4-13(14)18-16(20)22/h2-5,10-12H,6-9H2,1H3,(H,17,21)(H,18,22)/t10-,11+,12-
InChIKey
RWXRJSRJIITQAK-ZSBIGDGJSA-N
CAS Number
CAS 123258-84-4
PubChem Compound ID
6918106
Target and Pathway
Target(s) 5-HT 3 receptor Target Info Modulator [1572591]
References
Ref 524948ClinicalTrials.gov (NCT02259985) Effects of Food on the Bioavailability and Pharmacokinetic Profile of Itasetron After a Single Oral Dose in Healthy Male Subjects. U.S. National Institutes of Health.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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