Drug General Information
Drug ID	D02RAN
Former ID	DNC000789
Drug Name	Imetit
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538765]
Structure		Download 2D MOL 3D MOL
Formula	C6H10N4S
InChI	InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)
InChIKey	PEHSVUKQDJULKE-UHFFFAOYSA-N
CAS Number	CAS 519-23-3
PubChem Compound ID	3692
PubChem Substance ID	4725777, 7979594, 11111301, 11113668, 14772577, 15321889, 17182199, 26751853, 29222815, 47365323, 49846725, 50064072, 50104554, 50378622, 57309872, 57321944, 85209111, 90341548, 96024152, 103103017, 103184402, 104304247, 117401315, 124749884, 124880387, 124880388, 124880389, 128903678, 132556095, 134340115, 135072524, 135610596, 135650381, 136351577, 137132880, 138330873, 142231010, 142667100, 144235392, 162354693, 162769104, 179235712, 198952140, 226487103
Target and Pathway
Target(s)	Histamine H3 receptor	Target Info	Agonist	[536039]
	Histamine H4 receptor	Target Info	Agonist	[535960], [536161]
KEGG Pathway	Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction
Reactome	Histamine receptors
	G alpha (i) signalling eventsR-HSA-390650:Histamine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine Transport
	GPCRs, Class A Rhodopsin-like
	GPCR ligand binding
	GPCR downstream signalingWP1825:GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 538765	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1250).
Ref 535960	Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br J Pharmacol. 2004 May;142(1):161-71.
Ref 536039	The histamine H3 receptor: from gene cloning to H3 receptor drugs. Nat Rev Drug Discov. 2005 Feb;4(2):107-20.
Ref 536161	Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. J Neurophysiol. 2006 Apr;95(4):2492-500. Epub 2005 Dec 14.

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