Drug Information

Drug General Information
Drug ID
D02RUO
Former ID
DIB000070
Drug Name
ONO-8815Ly
Synonyms
ONO-8815Lyn; ONO-AE-1259
Drug Type
Small molecular drug
Indication Miscarriage [ICD10:O03] Terminated [539232], [547048]
Company
Ono Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL
Formula
C23H35ClO4
InChI
InChI=1S/C23H35ClO4/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h2-3,5,7,10,17-21,25-26H,1,4,6,8-9,11-16H2,(H,27,28)/b5-3-,10-7+/t17-,18-,19-,20-,21+/m1/s1
InChIKey
XXTBGKDWFYXGDZ-KJCKJCAZSA-N
CAS Number
CAS 433232-03-2
PubChem Compound ID
5311228
PubChem Substance ID
7979734, 11056359, 24263854, 39340936, 77035406, 103928280, 114155607, 135650767, 242645572
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Agonist [531621]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 539232(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1932).
Ref 547048Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800012532)
Ref 531621Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability. Arthritis Res Ther. 2011;13(5):R146.

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