Drug Information

Drug General Information
Drug ID
D02VFF
Former ID
DIB021181
Drug Name
VU0357121
Synonyms
VU 0357121
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541536]
Structure
Download
2D MOL
Formula
C17H17F2NO2
InChI
InChI=1S/C17H17F2NO2/c1-2-3-10-22-14-7-4-12(5-8-14)17(21)20-16-9-6-13(18)11-15(16)19/h4-9,11H,2-3,10H2,1H3,(H,20,21)
InChIKey
AHCYOTLTLQTPSU-UHFFFAOYSA-N
PubChem Compound ID
2296132
PubChem Substance ID
2709194, 3533603, 5281759, 8998862, 26125026, 29792696, 49910643, 51963602, 57785811, 89274399, 111037115, 131688139, 152159618, 152258704, 160647538, 162011721, 162249080, 163323440, 163341449, 164777571, 170128066, 172087018, 172919854, 174006273, 178103015, 179352082, 185974230, 187072851, 223705402, 242060094, 252158061, 252160547, 252216595, 252553681
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Modulator (allosteric modulator) [531240]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 541536(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6399).
Ref 531240Discovery of a Novel Chemical Class of mGlu(5) Allosteric Ligands with Distinct Modes of Pharmacology. ACS Chem Neurosci. 2010 Oct 20;1(10):702-716. Epub 2010 Aug 19.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.