Drug Information

Drug General Information
Drug ID
D02YPG
Former ID
DAP000669
Drug Name
Etomidate
Synonyms
Absele; Amidate; Ethnor; Ethomidate; Etomidato; Etomidatum; Hypnomidate; Radenarcon; Radenarkon; Etomidic acid; R 16659; R 26490; R26490; Amidate (TN); Amidate (pharmaceutical); Amidate, Etomidate; D-Etomidate; Etomidato [INN-Spanish]; Etomidatum [INN-Latin]; R-26490; Etomidate (USAN/INN); Etomidate [USAN:BAN:INN]; Ethyl 3-(1-phenylethyl)imidazole-4-carboxylate; Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate; R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate; (+)-Ethyl 1-(alpha-methylbenzyl)imidazole-5-carboxylate; (+)-Etomidate; (R)-(+)-1-(alpha-Methylbenzyl)imidazole-5-carboxylic acid ethyl ester; (d)-Etomidate; 1-(1-Phenylethyl)-1H-imidazole-5-carboxylic acid ethyl ester; 1-(1-Phenylethyl)-imidazole-5-carboxylic acid, ethyl ester; 1-(alpha-Methylbenzyl)-1H-imidazole-5-carboxylic acid ethyl ester; 1H-Imidazole-5-carboxylic acid, 1-((1R)-1-phenylethyl)-, ethyl ester; 3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ethyl ester
Drug Type
Small molecular drug
Indication Anesthesia [ICD9: 338; ICD10:R20.0] Approved [536300], [540865]
Therapeutic Class
Analgesics
Company
Janssen Pharmaceutica
Structure
Download
2D MOL

3D MOL
Formula
C14H16N2O2
InChI
InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
InChIKey
NPUKDXXFDDZOKR-LLVKDONJSA-N
CAS Number
CAS 33125-97-2
PubChem Compound ID
667484
PubChem Substance ID
9725, 866327, 7847614, 7979207, 9276664, 11114097, 12013395, 14749667, 24894630, 26719784, 46386983, 46507012, 49681795, 57408487, 75344057, 81093301, 91746212, 92308548, 99437359, 103190627, 104018111, 109839974, 113635237, 124659040, 124799994, 126608876, 128737179, 131310756, 135683824, 135698317, 135727028, 140492257, 152059471, 162023016, 162035908, 162166026, 162175645, 172080427, 172091164, 172913749, 174477914, 175268838, 178102113, 179149386, 185977341, 210279200, 210281523, 223376509, 223454396, 223519035
SuperDrug ATC ID
N01AX07
SuperDrug CAS ID
cas=033125972
Target and Pathway
Target(s) GABA A receptor Target Info Modulator [556264]
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 536300Anaesthetic drugs: linking molecular actions to clinical effects. Curr Pharm Des. 2006;12(28):3665-79.
Ref 540865(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5463).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

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