TTD | Drug: D03ERS

Drug General Information
Drug ID	D03ERS
Former ID	DIB020431
Drug Name	MRS2500
Synonyms	MRS-2500; MRS 2500
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539076]
Structure		Download 2D MOL
Formula	C13H18IN5O8P2
InChI	InChI=1S/C13H18IN5O8P2/c1-15-10-9-11(18-12(14)17-10)19(5-16-9)7-2-8(27-29(23,24)25)13(3-6(7)13)4-26-28(20,21)22/h5-8H,2-4H2,1H3,(H,15,17,18)(H2,20,21,22)(H2,23,24,25)/t6-,7+,8+,13+/m1/s1
InChIKey	NMVWLEUONAKGCD-SMWKGLLFSA-N
PubChem Compound ID	44448831
PubChem Substance ID	103563603, 135650659, 160852427
Target and Pathway
Target(s)	P2Y purinoceptor 1	Target Info	Antagonist	[526866]
KEGG Pathway	Rap1 signaling pathway
	Neuroactive ligand-receptor interaction
	Platelet activation
Reactome	G alpha (q) signalling events
	P2Y receptors
	ADP signalling through P2Y purinoceptor 1
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signal amplification
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 539076	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1724).
Ref 526866	2-Substitution of adenine nucleotide analogues containing a bicyclo[3.1.0]hexane ring system locked in a northern conformation: enhanced potency as P2Y1 receptor antagonists. J Med Chem. 2003 Nov 6;46(23):4974-87.

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Drug Information