Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03GLH
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| Former ID |
DAP000314
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| Drug Name |
Aminolevulinic acid
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| Synonyms |
Aladerm; Aminolevulinate; Aminolevulinic; Kerastick; Delta-ALA; Delta-aminolevulinic acid; Levulinic acid, 5-amino-(8CI); Pentanoic acid, 5-amino-4-oxo-(9CI); 5-ALA; 5-Amino-4-oxopentanoate; 5-Amino-4-oxopentanoic acid; 5-Amino-4-oxovaleric acid; 5-Aminolevulinate; 5-Aminolevulinic acid; 5-amino-levulinate
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Photosensitizing Agents
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| Structure |
|
Download2D MOL |
|||
| Formula |
C5H9NO3
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| InChI |
InChI=1S/C5H9NO3/c6-3-4(7)1-2-5(8)9/h1-3,6H2,(H,8,9)
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| InChIKey |
ZGXJTSGNIOSYLO-UHFFFAOYSA-N
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| CAS Number |
CAS 106-60-5
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| PubChem Compound ID | |||||
| PubChem Substance ID |
3719, 841472, 5427092, 8144107, 8150474, 11342129, 11362312, 11364476, 11367038, 11369600, 11372726, 11374315, 11377762, 11485579, 11487714, 11489478, 11491469, 11492433, 11495396, 15170674, 24438516, 46506856, 47589325, 47662632, 50002793, 50122683, 51031867, 51091887, 53789366, 56320695, 56322917, 57319985, 85083671, 85291378, 92298402, 92712186, 93166418, 99451455, 103182993, 104098261, 104170099, 104293958, 108134724, 118693344, 121362447, 124799829, 125662954, 126523837, 126579879, 126630164
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| ChEBI ID |
ChEBI:17549
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| SuperDrug ATC ID |
L01XD04
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| SuperDrug CAS ID |
cas=000106605
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| Target and Pathway | |||||
| Target(s) | Delta-aminolevulinic acid dehydratase | Target Info | Inhibitor | [534911], [535413], [535718] | |
| BioCyc Pathway | Heme biosynthesis | ||||
| Tetrapyrrole biosynthesis | |||||
| KEGG Pathway | Porphyrin and chlorophyll metabolism | ||||
| Metabolic pathways | |||||
| PANTHER Pathway | Heme biosynthesis | ||||
| PathWhiz Pathway | Porphyrin Metabolism | ||||
| WikiPathways | Heme Biosynthesis | ||||
| Metabolism of porphyrins | |||||
| References | |||||
| Ref 468013 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4784). | ||||
| Ref 536361 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| Ref 534911 | A novel mutation of delta-aminolaevulinate dehydratase in a healthy child with 12% erythrocyte enzyme activity. Br J Haematol. 1999 Sep;106(4):931-7. | ||||
| Ref 535413 | Melatonin protects against delta-aminolevulinic acid-induced oxidative damage in male Syrian hamster Harderian glands. Int J Biochem Cell Biol. 2002 May;34(5):544-53. | ||||
| Ref 535718 | Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Nat Biotechnol. 2003 May;21(5):566-9. Epub 2003 Mar 31. | ||||
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