Drug Information

Drug General Information
Drug ID
D03JEW
Former ID
DNC013345
Drug Name
N-(1-(4-nitrobenzyl)piperidin-4-yl)-2-naphthamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528638]
Structure
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2D MOL

3D MOL
Formula
C23H23N3O3
Canonical SMILES
C1CN(CCC1NC(=O)C2=CC3=CC=CC=C3C=C2)CC4=CC=C(C=C4)[N+](=<br />O)[O-]
InChI
1S/C23H23N3O3/c27-23(20-8-7-18-3-1-2-4-19(18)15-20)24-21-11-13-25(14-12-21)16-17-5-9-22(10-6-17)26(28)29/h1-10,15,21H,11-14,16H2,(H,24,27)
InChIKey
BAYSOSKDAJWQFJ-UHFFFAOYSA-N
PubChem Compound ID
44431485
Target and Pathway
Target(s) 5-hydroxytryptamine 2A receptor Target Info Inhibitor [528638]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 528638Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.
Ref 528638Bioorg Med Chem Lett. 2007 Mar 15;17(6):1570-4. Epub 2007 Jan 8.Synthesis and in vitro binding studies of substituted piperidine naphthamides. Part II: Influence of the substitution on the benzyl moiety on the affinity for D2L, D4.2, and 5-HT2A receptors.

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