Drug Information

Drug General Information
Drug ID
D03KZM
Former ID
DAP001530
Drug Name
Tolvaptan
Synonyms
Samsca; OPC 41061; Benzazepine derivative, 32; OPC-41061; Samsca (TN); N-[4-(7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)-3-methylphenyl]-2-methylbenzamide; (-)-4'-((7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl)carbonyl)-o-tolu-m-toluidide; 7-Chloro-5-hydroxy-1-(2-methyl-4-(2-methylbenzoylamino)benzoyl)2,3,4,5-tetrahydro-1H-1-benzazepine
Drug Type
Small molecular drug
Indication Hypervolaemic hyponatraemia; Euvolaemic hyponatraemia [ICD9: 276.1; ICD10:E87.1] Approved [530677], [539410]
Heart failure [ICD9: 428; ICD10:I50] Phase 3 [530677], [539410]
Company
Otsuka; Winston Laboratories & Otsuka
Structure
Download
2D MOL

3D MOL
Formula
C26H25ClN2O3
InChI
InChI=1S/C26H25ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15,24,30H,5,8,13H2,1-2H3,(H,28,31)
InChIKey
GYHCTFXIZSNGJT-UHFFFAOYSA-N
CAS Number
CAS 150683-30-0
PubChem Compound ID
216237
PubChem Substance ID
9372812, 12015154, 14833208, 30419982, 47510146, 47657166, 51204548, 53789150, 57399753, 85210210, 85856516, 103375036, 103991970, 113461194, 124894207, 125341597, 126624049, 126646501, 126667032, 128023819, 134338710, 134340568, 135135410, 135651270, 135692541, 137249406, 138069831, 144206807, 152134154, 160827363, 162038188, 162172255, 163093186, 163391946, 163884836, 172085105, 172914598, 175424760, 179149970, 187072445, 196109765, 198993114, 204366097, 208265503, 211536279, 223383397, 223659992, 224337427, 226592757, 242060063
SuperDrug ATC ID
C03XA01
Target and Pathway
Target(s) Vasopressin V2 receptor Target Info Antagonist [530677], [537061]
KEGG Pathway Neuroactive ligand-receptor interaction
Vasopressin-regulated water reabsorption
Pathway Interaction Database Arf6 trafficking events
PathWhiz Pathway Vasopressin Regulation of Water Homeostasis
Reactome Vasopressin-like receptors
G alpha (s) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
WikiPathways GPCRs, Class A Rhodopsin-like
Regulation of Water Balance by Renal Aquaporins
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 539410(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2226).
Ref 530677Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
Ref 537061Antibody-mediated disruption of the interaction between PCSK9 and the low-density lipoprotein receptor. Biochem J. 2009 May 1;419(3):577-84.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.