Drug General Information
Drug ID
D03QWT
Former ID
DCL000778
Drug Name
Doripenem
Synonyms
Doribax; S 4661; S-4661; Doripenem (USAN/INN); (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Drug Type
Small molecular drug
Indication Urinary tract infections [ICD9: 599; ICD10:N39.0] Approved [529282], [533123]
Gram-positive bacterial infection [ICD9:] Phase 3 [536094]
Company
Shionogi; penisula
Structure
Download
2D MOL

3D MOL

Formula
C15H24N4O6S2
Canonical SMILES
CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O
InChI
1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
InChIKey
AVAACINZEOAHHE-VFZPANTDSA-N
CAS Number
CAS 148016-81-3
PubChem Compound ID
PubChem Substance ID
SuperDrug ATC ID
J01DH04
Target and Pathway
Target(s) Dihydropteroate synthetase Target Info Inhibitor [536094]
References
Ref 5292822007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 536094Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
Ref 536094Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.

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