Drug Information

Drug General Information
Drug ID
D03RMI
Former ID
DIB020265
Drug Name
LY2033298
Synonyms
LY 2033298; LY-2033298
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531654]
Structure
Download
2D MOL
Formula
C13H14ClN3O2S
InChI
InChI=1S/C13H14ClN3O2S/c1-5-7-9(15)10(11(18)16-6-3-4-6)20-13(7)17-12(19-2)8(5)14/h6H,3-4,15H2,1-2H3,(H,16,18)
InChIKey
CTEGQKDJTBWFHW-UHFFFAOYSA-N
PubChem Compound ID
11536903
PubChem Substance ID
16638992, 23661250, 26746581, 42654924, 79419704, 137233307, 137525781, 160829054, 162248579, 163093805, 163389788, 163841740, 172884106, 178100305, 180388156, 204402660, 223617411, 224265412, 225375111, 228978111, 244542926, 249729462, 252483310
Target and Pathway
Target(s) Muscarinic receptor Target Info Modulator (allosteric modulator) [529629]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 531654Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects. Mol Pharmacol. 2012 Jan;81(1):41-52.
Ref 529629Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10978-83.

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