Drug General Information
Drug ID	D03WHD
Former ID	DNC006890
Drug Name	6-amino-4-trifluoromethylquinolin-2(1H)-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528470]
Structure		Download 2D MOL 3D MOL
Formula	C10H7F3N2O
Canonical SMILES	C1=CC2=C(C=C1N)C(=CC(=O)N2)C(F)(F)F
InChI	1S/C10H7F3N2O/c11-10(12,13)7-4-9(16)15-8-2-1-5(14)3-6(7)8/h1-4H,14H2,(H,15,16)
InChIKey	LMXZMEMPGRLDIG-UHFFFAOYSA-N
PubChem Compound ID	16090308
Target and Pathway
Target(s)	mRNA of androgen receptor	Target Info	Inhibitor	[528470]
KEGG Pathway	Oocyte meiosis
	Pathways in cancer
	Prostate cancer
NetPath Pathway	EGFR1 Signaling Pathway
	AndrogenReceptor Signaling Pathway
	FSH Signaling Pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Coregulation of Androgen receptor activity
	Regulation of Androgen receptor activity
	Nongenotropic Androgen signaling
	Regulation of nuclear beta catenin signaling and target gene transcription
	FOXA1 transcription factor network
	Notch-mediated HES/HEY network
Reactome	Nuclear Receptor transcription pathway
	Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways	SIDS Susceptibility Pathways
	Integrated Pancreatic Cancer Pathway
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Nuclear Receptors
	Androgen receptor signaling pathway
References
Ref 528470	J Med Chem. 2006 Oct 19;49(21):6143-6.Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator.
Ref 528470	J Med Chem. 2006 Oct 19;49(21):6143-6.Discovery of 6-N,N-bis(2,2,2-trifluoroethyl)amino- 4-trifluoromethylquinolin-2(1H)-one as a novel selective androgen receptor modulator.

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