Drug Information

Drug General Information
Drug ID
D04CRN
Former ID
DAP000721
Drug Name
Atomoxetine
Synonyms
Tomoxetina; Tomoxetine; Tomoxetinum; Tomoxetina [Spanish]; Tomoxetine [INN]; Tomoxetinum [Latin]; Atomoxetine (INN); Attentin (TN); Strattera (TN); Tomoxetin (TN); (-)-Tomoxetine; (3R)-N-methyl-3-(2-methylphenoxy)-3-phenylpropan-1-amine
Drug Type
Small molecular drug
Indication Attention deficit hyperactivity disorder [ICD9: 314; ICD10:F90] Approved [536661], [542125]
Company
Eli Lilly
Structure
Download
2D MOL

3D MOL
Formula
C17H21NO
InChI
InChI=1S/C17H21NO/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15/h3-11,17-18H,12-13H2,1-2H3/t17-/m1/s1
InChIKey
VHGCDTVCOLNTBX-QGZVFWFLSA-N
CAS Number
CAS 82248-59-7
PubChem Compound ID
54841
PubChem Substance ID
3249493, 8183809, 11114266, 14749997, 15196878, 34718779, 46506160, 47510014, 48179683, 50070867, 51091800, 57313676, 74924255, 85731218, 85788174, 92714045, 103189006, 104024503, 104305955, 117535667, 126582523, 126629698, 126655720, 126684045, 126723363, 129474852, 134338009, 134358577, 135030248, 137171620, 140098827, 143495940, 152101253, 152234173, 160845669, 160963637, 163773677, 175265837, 178103695, 179151249, 196105295, 223540968, 223682620, 223992935, 225207579, 226420765
SuperDrug ATC ID
N06BA09
SuperDrug CAS ID
cas=083015263
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [536025], [536749]
PANTHER Pathway Adrenaline and noradrenaline biosynthesis
Reactome Na+/Cl- dependent neurotransmitter transporters
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
References
Ref 536661Anti-obesity drugs and neural circuits of feeding. Trends Pharmacol Sci. 2008 Apr;29(4):208-17. Epub 2008 Mar 18.
Ref 542125(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7118).
Ref 536025New drugs for the treatment of attention-deficit/hyperactivity disorder. Expert Opin Emerg Drugs. 2004 Nov;9(2):293-302.
Ref 536749Atomoxetine reverses attentional deficits produced by noradrenergic deafferentation of medial prefrontal cortex. Psychopharmacology (Berl). 2008 Sep;200(1):39-50. Epub 2008 Jun 22.

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